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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: Nature. 2020 Nov 11;588(7837):296–302. doi: 10.1038/s41586-020-2926-0

Extended Data Figure 9. The effect of NrCAM on excitatory synapse formation and function in vivo.

Extended Data Figure 9

a, Images of postsynapse PSD-95 and presynapse VGLUT1 within NrCAM-deletion astrocytes in L1 of the visual cortex. High magnification images (bottom) correspond to boxes (above). b, Quantification of average number of excitatory synaptic co-localized puncta within astrocyte territories. n= 15 cells per each condition from 3 mice. c, mEPSC traces from L2/3 pyramidal neurons following astrocyte control empty sgRNA or NrCAM sgRNA expression. d-g, Quantification of mEPSC amplitude (d-e; Cont= 16, NrCAM sgRNA= 14 cells from 4 mice) and frequency (f-g; Cont= 14, NrCAM sgRNA= 17 cells from each of 4 mice). At least n= 3 biological repeats. Student’s t-test (paired, p<0.05). Data represent means ± s.e.m.