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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: Nature. 2020 Nov 11;588(7837):296–302. doi: 10.1038/s41586-020-2926-0

Figure 2. Astrocyte-neuron synaptic cleft proteome.

Figure 2

a, Outline of proteomic approach. b, Left, Overlapping high-confidence proteins shared between the Split-TurboID and TurboID-surface enriched fractions. Right, Clustergram topology of proteins in selected functional categories. Note: node titles are gene name; size represents fold-enrichment over negative control. Neuronal enriched proteins (RNAseq expression ratio<1) and astrocyte enriched proteins (RNAseq expression ratio≧1.0) are represented as circle or diamond, respectively. Edges are shaded according to types of interactions (gray, iBioIDs; black, protein-protein interactions previously reported).