Table 3.
EGF Sensitive hepatic phosphoproteins involved in lipid metabolism.
| Protein | Phosphosite(s) | EGF effect |
|---|---|---|
| ACC | S267/S30/S263 | Decreased |
| ACLY | S455 | Decreased |
| ACACA | S29 | Decreased |
| COASY | S177 | Decreased |
| ACOT1 | S56/S461 | Increased/Decreased |
| LPIN1 | S106 | Decreased |
| OATPB | S115 | Decreased |
| LDLR | S1418 | Decreased |
Note: “EGF Effect” refers to the expression of the relevant phosphorylated protein in mice injected with EGF ( IP) versus those injected with saline followed by liver extraction within 30 min and hepatic phosphoproteomic analysis. ACC, acetyl-CoA carboxylase; ACLY, ATP citrate synthase; ACOT1, acyl-CoA Thioesterase 1; ACSS2, acyl-CoA synthetase short chain family member 2; COASY, coenzyme A synthase; EGF, epidermal growth factor; IP, intraperitoneal; LDLR, LDL receptor; LPIN1, lipin 1; min, minutes; OATPB, solute carrier organic anion transporter family member 2B1.