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. 2021 Mar 31;16(3):e0249239. doi: 10.1371/journal.pone.0249239

Fig 4. The effect of GIPR antagonism alone or in combination with liraglutide on lipid homeostasis in DIO mice.

Fig 4

Effects of GIPA-1 and GIPA-2 on plasma TG (A and B), FFAs (C and D), TC (E and F), epididymal fat weight (G and H) and mesenteric fat weight (I and J) following administration of vehicle, liraglutide, GIPR antagonist, and liraglutide in combination with the GIPR antagonist for 28 days in DIO mice. Group sizes are n = 10, and data are represented as mean ± SEM. Statistical analysis was calculated using one-way ANOVA with Dunnett’s post-hoc test. *: p< 0.05, **: p < 0.01, ***: p < 0.001, ****: p<0.0001 compared to vehicle.