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. Author manuscript; available in PMC: 2021 Aug 5.
Published in final edited form as: Crit Rev Toxicol. 2020 Aug 5;50(6):474–490. doi: 10.1080/10408444.2020.1787330

Table 3.

NTP Final hazard conclusions by time period. The four possible level of evidence ratings are: High, Moderate, Low, or Inadequate. The five possible NTP final hazard identification conclusions are: Known, Presumed, Suspected, Not Classifiable, or Not Identified to be a Hazard to Humans.

Outcome Time Period Level of Evidence Rating (Human/Animal) NTP Final Hazard Conclusion
Cholinesterase Initial High/Moderate Known
Intermediate Low/Moderate Suspected
Extended Inadequate/Inadequate Not Classifiable
Vision & Ocular Effects Initial Moderate/Inadequate Suspected
Intermediate Moderate/Inadequate Suspected
Extended Low/Inadequate Not Classifiable
Learning, Memory, & Intelligence Initial Inadequate/Low Not Classifiable
Intermediate Low/Low Not Classifiable
Extended Moderate/Low Suspected
Morphological & Histological Effects Initial Inadequate/Moderate Suspected
Intermediate Inadequate/Moderate Suspected
Extended Moderate/Inadequate Suspected