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. Author manuscript; available in PMC: 2021 Mar 31.
Published in final edited form as: Int Rev Psychiatry. 2017 Dec 8;29(6):555–566. doi: 10.1080/09540261.2017.1396205

Table 1.

PET studies quantifying cortical dopamine in early psychosis.

Study Populations Anti-psychotic naïve/free Mean duration of psychotic illness Radiotracer & challenge Findings
Talvik et al. (2003) 8 HC
9 FEP		 —
9/0		 —
<5 years		 [11C]FLB 457 No group difference in dopamine receptor density in ACC and frontal cortex
Slifstein et al. (2015) 21 HC
20 FEP		 —
6/14		 —
13.2 ± 11.3 (SD) months		 [11C]FLB 457 baseline and with amphetamine

  1. No group difference in dopamine receptor density in cortex (including dlPFC, OFC, mPFC, ACC)

  2. Reduced amphetamine-induced dopamine release in patients with FEP in cortex (including dlPFC, OFC, mPFC, ACC), trend to statistical significance only in dlPFC

dlPFC: dorsolateral prefrontal cortex; HC: healthy controls; mPFC: medial prefrontal cortex; ACC: anterior cingulate cortex; OFC: orbifrontal cortex.