. Author manuscript; available in PMC: 2021 Mar 31.

Published in final edited form as: Int Rev Psychiatry. 2017 Dec 8;29(6):555–566. doi: 10.1080/09540261.2017.1396205

Table 3.

PET studies quantifying CB1 receptors in early psychosis.

Study	Populations	Anti-psychotic naive/free	Mean duration of psychotic illness	Radiotracer (outcome measure)	Findings
Ceccarini et al. (2013)	12 HC 16 unmedicated SCZ and 51 medicated SCZ including FEP and chronic SCZ	— 6/10	— Unmedicated SCZ: 5 ± 11 (SD) years unmedicated FEP: <1 year	[¹⁸F]MK9470 (modified SUV)	Increased binding in SCZ: unmedicated SCZ > medicated SCZ > HC
Ranganathan et al. (2016)	18 HC 7 unmedicated and 18 medicated SCZ	— 6/1	— NR	[¹¹C]OMAR (Vt)	Decreased binding in SCZ: unmedicated SCZ < medicated SCZ < HC

HC: healthy controls; NR: not reported; SCZ: schizophrenia.