Table 2.
Ongoing clinical trials on Gulf War Illness (GWI) posted at Clinicaltrials.gov.
| Study title | Objective and participants | NCT number | Recruitment status | Trial type/Phase | Results |
|---|---|---|---|---|---|
| Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness | To investigate whether intranasal insulin is an effective, safe, and affordable therapy for veterans with GWI (114 participants). | NCT01802944 | Unknown | Phase II, Randomized | Not Available |
| CAM in Veterans With Gulf War Illnesses | To explore the effectiveness Gulf War Health Education (GWHE) and iRest Yoga Nidra (meditation)/auricular (ear) acupuncture for veterans with GWI (172 participants). | NCT02180243 | Active, not Recruiting | Phase I & II, Randomized | Not Available |
| Gulf War Illness Inflammation Reduction Trial | To determine if treatment with an anti-inflammatory drug (delayed-release prednisone) improves the health-related quality of life (HRQOL) of veterans with Gulf War Illness (100 participants). | NCT02506192 | Recruiting | Randomized | Not Available |
| Novel Interventions for GWVI | To examine the beneficial effects of two novel treatments for GW Veteran’s Illness (Tai Chi and Wellness intervention) and to establish the efficacy of these mind-body approaches to symptom reduction (120 participants). | NCT02661997 | Recruiting | Randomized | Not Available |
| Mitochondrial Cocktail for Gulf War Illness | To develop effect size and variance estimates, to guide successful conduct of a properly-powered clinical trial to assess the benefit of a mitochondrial cocktail in GWI (32 participants). | NCT02804828 | Not yet Recruiting | Randomized | Not Available |
| CoQ10 in Gulf War Illness | To determine if treatment with ubiquinol, a form of coenzyme Q10, improves the physical function of men and women Veterans suffering from GWI (200 participants) | NCT02865460 | Active, not Recruiting | Randomized | Not Available |
| Effect of Diet on Gulf War Illness | To compare a low fermentable oligo-, di and mono-saccharides and polyols FODMAP - modified healthy) diet to a high FODMAP (typical healthy) diet for effect on veterans with irritable bowel syndrome (IBS) and symptoms of GWI (68 participants). |
NCT02881944 | Unknown | Randomized | Not Available |
| Effects of Botanical Microglia Modulators in Gulf War Illness | To test the effects of nine different botanical compounds (supplements) that are known to suppress inflammation (64 participants). | NCT02909686 | Active, not Recruiting | Randomized | Not Available |
| D-cycloserine: A Novel Treatment for Gulf War Illness | To investigate the efficacy of d-cycloserine treatment for Gulf War Illness (56 participants). | NCT02983734 | Recruiting | Phase II Randomized | Not Available |
| Probiotic (Vibiome) for Gulf War Illness | To determine whether VSL #3 will improve intestinal symptoms of IBS and non-intestinal symptoms (fatigue, joint pain, insomnia, general stiffness and headache) associated with IBS (60 participants). | NCT03078530 | Unknown | Phase II & III | Not Available |
| Treatment of Memory Disorders in Gulf War Illness With High Definition Transcranial Direct Cortical Stimulation | To determine if delivery of High definition transcranial direct current stimulation (HD tDCS) over the presupplementary motor area (preSMA) will improve performance in GWI veterans with a verbal retrieval deficit (120 participants). |
NCT03542383 | Recruiting | Randomized | Not Available |
| Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness | To investigate long-term modulation of pain pathways leading to a suppression of pain symptoms in GWI patients by applying transcranial direct current stimulation (120 participants). | NCT03547869 | Recruiting | Randomized | Not Available |
| Multimodal Investigation of the Neuroprotective Effects of Resveratrol | To examine the efficacy of resveratrol treatment for improving memory, thinking and mood in veterans with GWI (68 participants). | NCT03665740 | Recruiting | Randomized Double-blind, Placebo controlled | Not Available |
| Repetitive transcranial magnetic stimulation in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness | To investigate the effectiveness of using repetitive transcranial magnetic stimulation in relieving pain and other co-morbid symptoms of Gulf War Illness (80 participants). | NCT04046536 | Recruiting | Randomized | Not Available |
| Long Term Efficacy of Neuronavigation Guided tepetitive transcranial magnetic stimulation in Alleviating GWI Related Headaches and Pain Symptoms | To examine the long term efficacy of using repetitive transcranial magnetic stimulation in relieving GWI related headaches and pain (150 participants). | NCT04182659 | Recruiting | Randomized | Not Available |
| Tumor Necrosis Factor and Glucocorticoid Antagonist for GWI-Associated Multi-symptom Disease Homeostasis Reset | To assess the safety and mechanistic efficacy of a sequential etanercept-mifepristone intervention for GWI (20 participants). | NCT04254627 | Recruiting | Randomized | Not Available |
| Understanding GWI: Integrative Modeling | To assess the safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with GWI (20 participants). | NCT04255498 | Recruiting | Non-Randomized | Not Available |