Table 2.

Point values for ACMG/AMP strength of evidence categories

Evidence	Point Scale
Strength	Pathogenic	Benign
Indeterminate	0	0 §
Supporting	1	−1
Moderate	2	−2 †
Strong	4	−4
Very Strong	8	−8 †

^§Note is made that Richards et al did not specifically recognize indeterminate evidence. Nonetheless, if one thinks of the odds in favor of pathogenicity as a continuous variable, there exists a range that falls between Supporting Benign and Supporting Pathogenic. This is Indeterminate.

^†Note is also made that Richards et al did not specify benign evidence at the moderate or very strong levels. Nevertheless, the point system would readily support the addition of such criteria.