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. Author manuscript; available in PMC: 2022 Jan 27.
Published in final edited form as: Annu Rev Med. 2021 Jan 27;72:119–134. doi: 10.1146/annurev-med-080919-112707

Figure 1.

Figure 1

Distribution of participants in the Framingham Offspring Cohort (FOC) and the Copenhagen City Heart Study (CCHS) grouped into four lung function trajectories (TR1 to TR4) according to baseline FEV1 (below or above 80% predicted value) and presence or absence of GOLD grade ≥ 2 COPD at the final examination. Solid lines represent the natural history of FEV1 for the age range of the study while dotted lines represent hypothetical trajectories. Abbreviations: COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in one second; GOLD, Global Initiative for Obstructive Lung Disease. Copyright © 2015 Massachusetts Medical Society. Figure adapted with permission from Massachusetts Medical Society (5).