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. 2021 Apr 1;131(7):e146221. doi: 10.1172/JCI146221

Figure 4. Functional activity of anti-Pfs230 requires active complement in humans.

Figure 4

Vaccine dosing refers to the amount of target antigen (47 μg Pfs25 or 40 μg Pfs230D1) contained in the total conjugate vaccine dose. Sera from subjects vaccinated with Pfs230D1-EPA/Alhydrogel or Pfs230D1-EPA+Pfs25-EPA/Alhydrogel were divided in 2 aliquots, and after complement inactivation of 1 aliquot, used for SMFA. Each data point represents the oocyst count from 1 mosquito. *P < 0.05 difference between postvaccine and prebleed sera from individuals, Wilcoxon matched pairs signed-rank test with Bonferroni adjustment. Each panel shows 5 pairwise tests. Figure data are also represented in Supplemental Table 6.