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Comparison of various MUC1 immunogens investigated in the literature and this work. A) Early vaccines utilized MUC1 peptides, which induced modest immune responses; B) MUC1 glycopeptides can enhance the immune responses. The native α-linkage between the glycan and the peptide backbone is susceptible to glycosidase cleavage. C) In this work, we investigate a MUC1 glycopeptide mimetic with the unnatural β-glycosyl linkage, which can help enhance the stability toward a glycosidase.
