Table 3. Reaction Conditions of the Acid-Catalyzed Cyclization of CBD Using CSA^a.

				reaction mixture composition (%)b
entry	solvent	T (°C)	time (h)	Δ9-THC	Δ8-THC	Δ8-iso-THC
1	Tol	RT	48
2	Tol	RT	96	61
3	Tol	RT	120	20	28
4	Tol	30	96	53	20
5	Tol	40	24	48	19
6	Tol	40	48	45	52
7	Tol	40	72	28	72
8	Tol	40	96	13	87
9	Tol	50	3	37	10
10	Tol	50	4	62	19
11	CH2Cl2	RT	24	33	5
12	CH2Cl2	RT	48	64	36
13	CH2Cl2	30	24	48	52
14	n-Hex	30	96	31	41
15	MTBE	30	96	54	26	9
16	cyclohexane	30	96	NR	NR	NR

^aRT, room temperature; NR, no reaction.

^bDetermined via HPLC and ¹H NMR analysis.