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. Author manuscript; available in PMC: 2021 May 14.
Published in final edited form as: J Med Chem. 2020 Apr 29;63(9):4790–4810. doi: 10.1021/acs.jmedchem.0c00015

Scheme 2. Preparation of 8a-8fa.

Scheme 2.

aReagents and conditions: (i) bromoacetic acid, HATU, DIEA, dichloromethane, 0°C to r.t.; (ii) corresponding 7-substituted 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide, Na2CO3, DMF, 40°C.