. Author manuscript; available in PMC: 2021 May 14.

Published in final edited form as: J Med Chem. 2020 Apr 29;63(9):4790–4810. doi: 10.1021/acs.jmedchem.0c00015

Table 4.

Antiviral activity against HIV-1 (III_B) and HIV-2 (ROD) replicating in MT-4 cells. Corresponding cytotoxicity, and selectivity indices are also given.

Compounds	EC₅₀^a(μM)		CC₅₀^b(μM)	SI^c
Compounds	IIIb	ROD	CC₅₀^b(μM)	IIIB	ROD
6k	24.48±8.73	20.06±4.44	136.28±5.26	5.57	6.79
8a	6.07±2.93	2.72±1.09	129.72±4.88	21.37	47.69
11a	0.71±0.37	0.032±0.009	108.54±17.00	152.87	3391.88
11i	4.90±1.87	0.16±0.05	8.89±1.94	1.81	55.56
11l	0.21±0.03	0.031±0.012	178.81±1.21	851.48	5768.06
PF-74	0.87±0.31	3.69±0.59	145.18±38.05	166.87	39.34

EC₅₀: concentration of compound required to achieve 50% protection of MT-4 cell cultures against HIV-1-induced cytotoxicity, as determined by the MTT method.

CC₅₀: concentration required to reduce the viability of mock-infected cell cultures by 50%, as determined by the MTT method.

SI: selectivity index, the ratio of CC₅₀/EC₅₀.