Table 5.
SPR results of representative compounds and PF-74 binding to monomeric and hexameric CA constructs.
| Compound | KDa (μM) | ratiob | |
|---|---|---|---|
| Monomer | Hexamer | ||
| 6a | 15.50±1.76 | 11.80±0.30 | 1.31 |
| 6k | 22.10±12.00 | 7.99±0.08 | 2.77 |
| 8a | 6.63±1.46 | 1.19±0.05 | 5.57 |
| 8d | 0.20±0.07 | 1.30±0.22 | 0.15 |
| 11i | 11.50±5.92 | 4.45±0.32 | 2.58 |
| 11l | 13.60±7.86 | 2.63±0.14 | 5.17 |
| 11m | 10.00±4.38 | 3.02±0.13 | 3.31 |
| PF-74 | 2.80±1.40 | 0.093±0.005 | 30.11 |
a
All values represent the average response from at least 3 replicates. Error bars represent standard deviation.
b
KDMonomer/KDHexamer ratio.