Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Antiviral activity in early-, late-stages of representative compounds using HIV-1 Env-pseudotyped virus.
| Compound | IC50a (μM) | Ratiob | |
|---|---|---|---|
| Early Stage | Late Stage | ||
| 6k | 8.22 ± 0.99 | 4.20 ± 2.51 | 0.51 |
| 8a | 1.94 ± 0.48 | 2.44 ± 1.52 | 1.26 |
| 11l | 8.96 ± 0.43nM | 0.24 ± 0.11 | 26.79 |
| PF-74 | 56 ± 17 nM | 0.23 ± 0.17 | 4.11 |
the concentration of the compound required to achieve 50% infection of HIV-1 Env-pseudotyped virus in U87.CD4.CCR5 target cells. SD of 3 parallel tests is indicated.
IC50Late/IC50Early ratio.
