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. 2021 Mar 23;2021:5542545. doi: 10.1155/2021/5542545

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Copyright © 2021 Lei Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Sirt-1 regulates p53's transcriptional activity and its downstream gene. (a) After stable knockdown or overexpression of Sirt-1, FOXO and p53 levels were analyzed by performing western blot. (b) By performing fluorescent reporter assay, the effect of Sirt-1 on p53's transcriptional activity was measured. ^∗P < 0.05, vs. vector group; ^△P < 0.05, vs. scrambled group. (c) RT-qPCR was performed to detect mRNA levels of p53's downstream target genes, including p21, Bax, and Bcl-2. ^∗P < 0.05, vs. vector group; ^△P < 0.05, vs. scrambled group.