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Sirt-1 indirectly regulates p21 depending on p53's transcriptional activity. p21 mRNA (a) and protein levels (b) were measured with or without the presence of 30 μM pifithrin-α, an inhibitor of p53 transcriptional activity. ∗P < 0.05, vs. vector group; △P < 0.05, vs. scrambled group. (c) Chromatin immunoprecipitation was performed to further confirm the effect of Sirt-1 on the binding of p53 to p21 promoter region. ∗P < 0.05, vs. vector group; △P < 0.05, vs. scrambled group.
