Figure 9.

Sirt-1 protects cells from oxidative stress induced by H₂O₂ via its deacetylation activity. (a) Adding 200 mM H₂O₂, the percentage of cell viabilities in the vector group, Sirt-1 group, scrambled group, and shSirt-1 group were measured. Sirt-1 presence protects cells from H₂O₂-induced decrease in cell viability. ^∗P < 0.05, vs. vector group. (b, c) The percentage of apoptosis in the vector group, Sirt-1 group, scrambled group, shSirt-1 group, and EX527 group was measured. Sirt-1 exerts protective effects on cell viability and cell survival from apoptotic cell death depending on its deacetylation activity.