Table 4.
Described impact of mutations on SARS-CoV-2 genome and TMPRSS2 gene on host miRNAs function.
| miRNAs affected | Target | Mutation/SNP | Results | References |
|---|---|---|---|---|
| miR-3162-3p | SARS-CoV-2 | 28,881-3 Nucleopcasid gene GGG --> AAC | Disruption of target site | Maitra et al., 2020 |
| miR-6826-3p | ||||
| miR-5195-5p | ||||
| miR-24-1-5p | ||||
| miR-3679-3p | ||||
| miR-642b-5p | ||||
| miR-24-2-5p | ||||
| miR-4699-3p | SARS-CoV-2 | 28,881-3 Nucleopcasid gene GGG --> AAC | Creation of target site | Maitra et al., 2020 |
| miR-299-5p | ||||
| miR-12,132 | ||||
| miR-197-5p | SARS-CoV-2 | ORF1a (Nsp3) C3037U | Disruption of target site | Rad and McLellan, 2020 |
| miR-3935-5p | SARS-CoV-2 | ORF1a (Nsp4) A9259G | Disruption of target site | |
| miR-18b-5p | SARS-CoV-2 | ORF1a (Nsp4) G9802U | Disruption of target site | |
| miR-18b-5p | SARS-CoV-2 | ORF1a (Nsp4) C9803U | Disruption of target site | |
| miR-1273d | SARS-CoV-2 | ORF1b (Nsp12) C15293U | Disruption of target site | |
| miR-4661-3p | SARS-CoV-2 | S G25311U | Disruption of target site | |
| miR-338-3p | SARS-CoV-2 | S C24034U | Disruption of target site | |
| miR-338-3p | SARS-CoV-2 | S G24057A | Disruption of target site | |
| miR-6729-5p | TMPRSS2 | rs75036690 miRNA Seed region AGGAGU[G/C] | Disruption of target site | Paniri et al., 2020 |
| miR-433b-3p | TMPRSS2 | rs12473206 miRNA Seed region AGGAGU[G/C] | Creation of target site | |
| miR-548c-3p | TMPRSS2 | rs456142 miRNA target site G/A | Break of target site | |
| miR-127-3p | TMPRSS2 | rs462574 miRNA target sites T/C | Creation of target site | |
| miR-1324 | TMPRSS2 | rs462574 miRNA target sites T/C | Break of target site | |
| miR-5089 | TMPRSS2 | rs456298 miRNA target sites T/A | Creation/enhancement of target site | |
| miR-204-5p | TMPRSS2 | rs12627374 miRNA target sites G/A | Decrease affinity with target site | |
| miR-211-5p | TMPRSS2 | rs12627374 miRNA target sites G/A | Enhance affinity with target site | |
| miR-4685-3p | TMPRSS2 | rs12627374 miRNA target sites G/A | Decrease affinity with target site | |
| miR-4716-5p | TMPRSS2 | rs12627374 miRNA target sites G/A | Creation of target site |