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. 2020 Jul 6;24(1):1–14. doi: 10.1038/s41391-020-0245-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Acute exercise increases tumour blood flow and tumour vascular resistance is reduced. b Augmented tumour perfusion pressure as a result of increased tumour blood flow may lead to greater oxygen (O₂) diffusion distance and thus reduce diffusion-limited hypoxic tumour areas. c Tumour vasculature is dysfunctional and structurally abnormal, resulting in heterogeneous and variable tumour blood flow. Exercise increases the area of tumour perfusion and therefore reduces perfusion-limited hypoxia. Created with BioRender.com.