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. 2020 Jul 6;24(1):1–14. doi: 10.1038/s41391-020-0245-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Systemic effects of augmented cardiac output and increased arterial pressure resulting from mild hyperthermia and increased stroke volume and heart rate in response to acute exercise (top panel) may influence local physiological responses and vascular adaptation in the tumour microenvironment (bottom panel). Improved tumour perfusion, either as a result of increased systemic blood flow during exercise or as a result of vascular maturation, may enhance acute and chronic oxygenation of hypoxic tumour areas, thus resulting in improved radiotherapy efficacy.