Table 2:

Univariate and multivariate analysis of ctDNA VAF

	Univariate analysis		Multivariate analysis
Characteristic	HR (95% CI)	P-value	HR 95% CI	P-value
Histology	0.94 (0.70 – 1.27)	0.694
Immunotherapy exposure	1.03 (0.75 – 1.43)	0.845
Visceral metastasis	1.66 (1.27 – 2.19)	< 0.001	1.48 (1.16 – 1.91)	0.002
CNS metastasis	1.33 (1.00 – 1.79)	0.053
RECIST SLD	1.05 (1.03 – 1.08)	< 0.0001
CT volume	1.00 (1.00 – 1.00)	< 0.0001	1.00 (1.00 – 1.00)	< 0.001
TP53+	1.58 (1.25 – 2.00)	< 0.001	1.45 (1.16 – 1.80)	0.001
EGFR+	1.19 (0.92 – 1.53)	0.179	1.36 (1.08 – 1.71)	0.009
KRAS+	1.22 (0.91 – 1.64)	0.178