FIGURE 4.

[¹⁸F]MK6240 uptake in domain‐specific analyses of the Neuropsychiatric Inventory Questionnaire (NPI‐Q). There were different patterns of association of [¹⁸F]MK6240 uptake with NPI‐Q domains; agitation was related to tau‐positron emission tomography uptake in the orbitofrontal cortex, ventromedial prefrontal cortex, the temporal lobes, and the precuneus. The anxiety domain showed a positive correlation with uptake in the cuneus, the superior frontal gyrus, and the parahippocampal gyrus. Apathy correlated with [¹⁸F]MK6240 uptake in the parietal association area. Delusions, however, showed cuneus/occipital uptake. Depression presented uptake in the superior temporal gyrus and the parietal association area. Moreover, disinhibition was positively related with uptake in the occipital and temporal lobes and parahippocampal gyrus. Elation on the other end presented uptake in the precuneus, anterior cingulate, medial frontal, and parahippocampal regions. In the case of hallucinations, [¹⁸F]MK6240 presented signals in the occipital lobe. Irritability was related to frontal pole uptake, while motor disturbance was associated with uptake in pre/postcentral region, as well as parietal association area, occipital, and cingulate. Finally, regarding night‐time behavior, the severity score was associated with uptake of the tracer in the medial frontal region