TABLE 1.
Demographic characteristics of the sample
| Overall | CU | MCI | AD | P | |
|---|---|---|---|---|---|
| N | 221 | 143 | 52 | 26 | |
| N symptomatic (%) | 108 (48.87) | 44 (30.77) | 39 (75.99) | 25 (96.15) | <0.001 |
| Age, mean (SD) | 71.59 (6.45) | 72.15 (5.68) | 71.75 (7.49) | 68.21 (7.40) | 0.016 |
| Male, n (%) | 92 (41.63) | 49 (34.27) | 30 (57.69) | 13 (50.00) | 0.011 |
| Education, mean (SD) | 15.25 (3.62) | 15.44 (3.55) | 15.14 (3.99) | 14.42 (3.26) | 0.409 |
| MMSE, mean (SD) | 27.59 (4.09) | 29.01 (1.21) | 27.75 (1.87) | 19.32 (7.15) | <0.001 |
| CDR, mean (SD) | 0.25 (0.41) | 0.00 (0.00) | 0.50 (0.00) | 1.08 (0.51) | <0.001 |
| Amyloid positivity (%)a | 89 (40.3) | 30 (21.0) | 33 (63.5) | 26 (100.0) | < 0.001 |
| Tau positivity (%)b | 80 (37.9) | 27 (18.9) | 29 (55.8) | 24 (92.3) | < 0.001 |
|
[18F]MK6240 Parietal/occipital/temporal/ frontal SUVR, mean (SD) |
1.23 (0.35) | 1.12 (0.13) | 1.19 (0.21) | 1.89 (0.61) | < 0.001 |
| [18F]MK6240 Braak 1 and 2 SUVR, mean (SD) | 1.14 (0.38) | 0.97 (0.18) | 1.35 (0.46) | 1.63 (0.40) | < 0.001 |
| [18F]MK6240 Braak 3 and 4 SUVR, mean (SD) | 1.33 (0.65) | 1.07 (0.12) | 1.44 (0.69) | 2.51 (0.91) | < 0.001 |
| [18F]MK6240 Braak 5 and 6 SUVR, mean (SD) | 1.28 (0.51) | 1.10 (0.14) | 1.28 (0.38) | 2.24 (0.87) | < 0.001 |
| Atrophy score, mean (SD)c | 2.87 (0.19) | 2.94 (0.13) | 2.84 (0.18) | 2.57 (0.21) | < 0.001 |
Abbreviations: AD, Alzheimer's disease; CDR, Clinical Dementia Rating; CU, cognitively unimpaired; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; SD, standard deviation; r SUVR, standardized uptake value ratios.
aBased on Therriault et al. 15
b
Based on visual rating.
c
Based on Jack et al. 25