TABLE 3.

Summary of the NPI‐Q domain results with [¹⁸F]MK6240 uptake, and relation with brain regions

Symptom	Brain image	Region	Role of region
Agitation		Ventromedial prefrontal cortex Orbitofrontal cortex Precuneus Temporal lobe	Processing of risk, fear and emotional responses Emotion and memory Recollection and memory Emotion association
Anxiety		Cuneus Superior frontal Parahippocampal gyrus	Vision‐related region, inhibition Working memory and executive processing Memory formation
Apathy		Parietal association area	Association of sensory information
Delusions		Cuneus	Vision‐related region, inhibition
Depression		Parietal association area Superior temporal gyrus	Association of sensory information Emotional processing and social cognition
Disinhibition		Superior temporal gyrus Cuneus Medial parietal Parahippocampus	Emotional processing and social cognition Vision related, inhibition Sensory information processing Memory formation
Elation		Precuneus Cingulate Medial frontal Parahippocampus	Recollection and memory Attention, decision making, and emotions Behavior regulation Memory formation
Hallucinations		Cuneus	Vision‐related region, inhibition
Irritability		Frontal pole	Behavior regulation
Motor disturbance		Pre‐/post‐central gyrus Parietal association area Occipital pole Cingulate	Motor‐relation region Association of sensory information Information processing Attention, decision making, and emotions
Night‐time behavior		Superior frontal gyrus	Behavior regulation

Abbreviation: NPI‐Q, Neuropsychiatric Inventory Questionnaire.