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. 2020 Jun 20;37(2):261–275. doi: 10.1007/s10565-020-09542-4

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© The Author(s) 2020

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Fig. 2 — a MSM increases DOX-induced apoptosis in EC cells. The results are expressed as % of gated cells. p < 0.05 was considered statistically significant. *p < 0.05, ***p < 0.001 as compared to Cnt. ##p < 0.01, ###p < 0.001 as compared to MSM treatment in the same dose. MSM methylsulfonylmethane, DOX doxorubicin, Cnt control. b Pre-treatment with MSM before DOX treatment increases mitochondrial potential in EC cells. The results are expressed as % of gated cells. p < 0.05 was considered statistically significant. *p < 0.05, ***p < 0.001 as compared to Cnt. ##p < 0.01, ###p < 0.001 as compared to MSM treatment in the same dose. MSM methylsulfonylmethane, DOX doxorubicin, Cnt control. c MSM increases DOX-induced DNA damage in EC cells. DNA damage was evaluated with Muse® Multicolor DNA damage. The results are expressed as % of cells gated. p < 0.05 was considered statistically significant. ***p < 0.001 as compared to Cnt. ###p < 0.001 as compared to MSM treatment. In DAPI staining with white arrows are marked fragmentated nuclei of cells. MSM methylsulfonylmethane, DOX doxorubicin, Cnt control