Table 1.

Commercially available hybrid closed-loop systems

Component	Medtronic 670G	Medtronic 780G	CamAPS FX	Control-IQ
Algorithm	PID with insulin feedback	PID with insulin feedback	Treat to target adaptive MPC (Cambridge algorithm)	Treat to range predictive algorithm
Insulin pump	670G	780G	Dana RS, Dana-i	Tandem t:slim X2
CGM system	Guardian 3 (requires ~4–6 fingersticks/day)	Guardian 3 (requires ~4 fingersticks/day)	Dexcom G6 (factory calibrated, optional calibration)	Dexcom G6 (factory calibrated, optional calibration)
Target glucose	Fixed target: 6.7 mmol/l	Target: 5.6 mmol/l (default) or 6.7 mmol/l	Target: 5.8 mmol/l (default); customisable between 4.4 mmol/l and 11 mmol/l	Fixed target range: 6.2–8.9 mmol/l
	Optional activity target	Optional activity target		Night mode: 6.2–6.7 mmol/l
			Optional activity target	Optional activity target
Algorithm learning	Based on TDD	Based on TDD	Adapts to prandial and diurnal patterns	None
Compatible downloading software	Carelink; manual downloading of pump required	Carelink; automated app compatibility	Diasend; automated download	Clarity: sensor data
				Diasend/Glooko; manual downloading of pump required

TDD, total daily dose