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. 2021 Jan 17;31(4):1767–1789. doi: 10.1007/s11695-020-05182-z

Table 3.

Post-operative body composition, weight loss, physical activity level, performance, cardiorespiratory fitness, energy expenditure, metabolic parameters, substrate use, and autonomic nervous system modulation

Author (year) Methods Results Post-surgery evaluation period (month)
1 2 3 4 5 6 7 12 14 16 17 18 ≥ 24
Alam et al. [22] RR and QT time series ↓BW (kg)
↓BMI (kg/m2)
↓HR (bpm) (at 6th)
↑QTVI (1st and 12th)
↓SampEn (QT) (at 1st)

↓DFAα (NN) (1st)

↓DFAα (QT) (1st)

↓RR (6th)
↓RMSSD (ms) (at 6th)
↓SDNN (ms) (at 6th)

↓HbA1c (%) (at 12th)

↓Rest systolic blood pressure (mmHg) (at 6th and 12th)

↓ Rest diastolic blood pressure (mmHg) (at 12th)
Alba et al. [23]

Gait speed and time to rise from a chair five times

+

400-m walk test

+

Handgrip strength

+

International Physical Activity Questionnaire (IPAQ)

↓FFM (kg)

↑Gait speed

↑Time for five chair stands

↓Absolute grip strength (at 6th and 12th)

↑Relative strength (at 6th and 12th)

↔ Self-reported physical activity

Benedetti et al. [14] Respiration chamber

↓FM (kg)

↓FFM (kg)

↓REE ((kcal/24 h))

↑Fasting npRQ

↓Fasting glucose (mmol/dl)

↓Fasting insulin (mU/ml)

↓Fasting FFA (mM)

Bobbioni-Harsch et al. [24]

Body impedance analyzer

+

A 120-min euglycemic, hyperinsulinemic clamp

+

Plasma levels of glucose and free fatty acids (FFA) were enzymatically determined

+

Heart rate variability (HRV): electrocardiograph continuously recorded for a 24-h period

↓BMI (kg/m2)

↓FM (kg)

↓FFM (kg)

↑Glucose uptake (mg/kg LBM/min)

↔ FFA (mEq)

↓Plasma insulin (ng/ml)

↑SDNN (ms)

↑RMS (ms)

↑% pNN 50

Bond et al. [25]

RT3 accelerometers

+

Paffenbarger Physical Activity Questionnaire (PPAQ)

55% comply with the recommendation (subjective assessment) versus 5% comply with the recommendation (objective assessment)
Braga et al. [26]

Digital scale and a tape measure

+

HOMA-IR and glucose were quantified by the glucose oxidase colorimetric method

+

Endothelial reactivity and HRV analysis were performed by peripheral arterial tonometry (PAT)

↓FM (kg)

↓FFM (kg)

↓AC (cm)

↔ HOMA-IR (%)

↓Fasting glucose (mg/dl)

↓Fasting insulin (IU/l)

↔ LnRHI

↔ AI

↔ AI@75

↓HR (bpm)

↑HRV-time domain

↓HRV-frequency domain (↑LF/HF)

↔ Systolic blood pressure (mmHg)

↔ Diastolic blood pressure (mmHg)

Browning et al. [27]

Treadmill with gas-exchange analysis

+

Stanford 7-day Physical Activity Recall (PAR)

↓BMI (kg/m2)

↓BW (kg)

↓FM (kg)

↓FFM (kg)

↓Submaximal HR (bpm)

↔ VO2 (l/min/kg)

↑Time to exhaustion (min)

↔ HRmax (bpm)

↔ Absolute VO2peak (l/min)

↑VO2peak (ml/kg/min)

↔ RERmax

↑VO2peak/pulse (ml/beat/kg)

↔ Post-exercise La (mmol/l)

Campos et al. [9]

Magnetic bioimpedance device

+

Lung function: computerized ultrasound spirometer with a flow sensor

+

Respiratory muscle strength: analog manometer

+

Functional capacity: incremental shuttle walk test (ISWT)

+

Baecke questionnaire

↓BMI (kg/m2)

↓BW (kg)

↓WC (cm)

↔ W/H

↓FM (kg)

↓FFM (kg)

↑SVC (l)

↑FVC (l)

↑FEV1 (l)

↑MIP (cmH2O)

↔ MEP (cmH2O)

↑Distance (m)

↔ PA level

Carrasco et al. [16]

Digital scale and a scale-mounted stadiometer + isotopic dilution with deuterium oxide (total body water)

+

Open-circuit indirect calorimetry using a ventilated chamber system

+

Simple survey to assess PA

+

HOMA-IR

↓BMI (kg/m2)

↓BW (kg)

↓WC (cm)

↓FM (kg)

↓FFM (kg)

↓W/HR

↓Fasting glucose (mg/dl)

↓Fasting insulin (μU/ml)

↓HOMA-IR

↓Total cholesterol (mg/dl)

↓LDL cholesterol (mg/dl)

↑HDL cholesterol (mg/dl)

↓Triglycerides (mg/dl)

↓Systolic blood pressure (mmHg)

↓Diastolic blood pressure (mmHg)

↓REE

↑Fasting lipid oxidation (%)

↑PA level

Colles et al. [17] Medical Outcomes Trust Short Form-36 (SF-36)

↓BW (kg)

↓BMI (kg/m2)

↑SF-36 PCS score (at 12th)

Daniel et al. [28] Treadmill with gas-exchange analysis

↓BMI (kg/m2)

↑METs max

↑Exercise time (s)

↑VO2peak (ml/min/kg)

↓VO2peak (ml/min)

Tau (τ) altered at 6th and improved at 16th

↔ RERmax

↑HR/VO2 slope (at 6th)

↓HR rest (bpm) (at 6th)

↓Rest systolic blood pressure (mmHg) (at 6th)

↓Rest diastolic blood pressure (mmHg) (at 6th)

Das et al. [29]

15-day doubly labeled water; indirect

Calorimetry

+

Minnesota Leisure Time Physical Activity (LTPA) questionnaire (structured interview)

↓BMI (kg/m2)

↓BW (kg)

↓FM (kg)

↓FM (%)

↓TEE (MJ/day)

↓REE (MJ/day)

↔ Physical activity level (TEE/REE)

↔ Reported activity (min/day)

Dereppe et al. [30] Graded cycle ergometer with gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓ Rest systolic blood pressure (mmHg)

↓ Rest diastolic blood pressure

↓Glucose (mg/dl)

↑HDL cholesterol (mg/dl)

↓LDL cholesterol (mg/dl)

↓Triglycerides (mg/dl)

↓VO2peak (ml/min)

↑VO2peak (ml/min/kg)

↓W (W)

↑RERmax

De Souza et al. [31] Treadmill with gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↑Distance covered (m)

↑Exercise duration (min)

↑VO2max (ml/kg/min)

De Souza et al. [32] 6-min walk test

↓BW (kg)

↓BMI (kg/m2)

↑Distance covered (m)

↓Perceived exhaustion

↓HR

↓Respiratory frequency

Galtier et al. [33]

Indirect calorimetry with gas-exchange analysis

+

HOMA-IR

+

Bioimpedance analysis

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓ Rest systolic blood pressure (mmHg)

↓ Rest diastolic blood pressure (mmHg)

↓Fat-free mass (kg)

↓Fat mass (%)

↔ Fasting blood glucose (mmol/l)

↓120-min OGTT blood glucose (mmol/l)

↓Fasting plasma insulin (mIU/l)

↓Peak-OGTT plasma insulin (mIU/l)

↓Total cholesterol (mmol/l)

↓Triglycerides (mmol/l)

↑HDL cholesterol (mmol/l)

↔ LDL cholesterol (mmol/l)

↓HOMA-IR

↓REE/FFM

↑REE/BW

↔ Lipid oxidation

A

A, B

B

Iannelli et al. [34]

Bioelectrical impedance analysis

+

Wall-mounted stadiometer and a digital electronic scale

+

Indirect calorimetry with gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓FFM (kg)

↓FM (%)

↓REE (kcal/24 h)

↓Glucose levels (mmol/l)

↓HOMA-IR

↓HbA1c (%)

↑HDL cholesterol (mmol/l)

↓LDL cholesterol (mmol/l)

↓Triglycerides (mmol/l)

Kanoupakis et al. [35]

Treadmill with gas-exchange analysis

+

M-mode, 2-dimensional, and Doppler echocardiography

↔ Rest HR (bpm)

↔ Rest systolic blood pressure (mmHg)

Anaerobic threshold

↔ HR (bpm)

↔ Systolic blood pressure (mmHg)

↓VO2 (ml/min)

↑VO2 (ml/kg/min)

↔ O2 pulse (ml/beat)

Maximal exercise

↔ HR (beats/min)

↔ Systolic blood pressure (mmHg)

↑Time (s)

↓VO2 (ml/min)

↑VO2 (ml/kg/min)

↔ O2 pulse (ml/beat)

↑Ventilation (l/min)

↑VCO2 production (ml/min)

↑METs

↓IVS (mm)

↓PW (mm)

↑E/A

↓IVRT (ms)

Kokkinos et al. [36]

Heart rate variability (HRV) (frequency domain)

+

Echocardiography

↓BMI (kg/m2) (at 3th and 6th)

↓Waist (cm) (at 3th and 6th)

↓Hip (cm) (at 3th and 6th)

↑LF (ms2) (for SG)

↑HF (ms2) (for SG and GB)

↔ LF/HF ratio

↑Total power (ms2) (for SG and GB)

↓Epicardial fat (mm) (at 6th) (for SG and GB)

↓LV Tei index (at 6th month) (for SG and GB)

↓LA diameter (mm) (at 6th) (for SG and GB)

↑EF (%) (at 6th) (for SG and GB)

↑LV mass index (g) (at 6th) (for SG and GB)

Li et al. [37]

Glucose oxidase method

+

High-performance liquid chromatography

+

Automatic analyzer

+

Electronic scale and fixed wall stadiometer

+

Segmental bioelectrical impedance analysis

+

Gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓FFM (kg)

↓FM (kg)

↓Rest systolic blood pressure (mmHg)

↔ Rest diastolic blood pressure (mmHg)

↓Total cholesterol (mmol/l)

↓Triglycerides (mmol/l)

↑HDL cholesterol (mmol/l)

↓LDL cholesterol (mmol/l)

↓Blood glucose levels

↓HbA1c (%)

↓RQ

↓REE (kcal)

↓REE/BW

↔ REE/FFM

Liu et al. [38]

Bioelectrical impedance analysis

+

Dual-energy x-ray absorptiometry

+

Treadmill with gas-exchange analysis

+

Accelerometer

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓Fat mass (kg)

↓REE (kcal/day)

↓REE/FFM

↔ Physical activity level

Lund et al. [39]

Stationary ergometer bike with gas-exchange analysis

+

Physical function was assessed by the SF-36 questionnaire

+

CAMB questionnaire

↓BW (kg)

↓BMI (kg/m2)

↓FFM (kg)

↓FM (%)

↓Fasting insulin (pmol/l)

↓Fasting glucose (mmol/l)

↓HbA1c (mmol/mol)

↓Fasting total cholesterol (mmol/l)

↓Systolic blood pressure (mmHg)

↔ Diastolic blood pressure (mmHg)

↓VO2 (ml/min)

↑VO2 (ml/kg/min)

↔ VO2 (ml/kgFFM/min)

↔ Exercise (h/week)

↔ Physical activity level

Machado et al. [40]

Electronic anthropometric scale

+

Heart rate variability (HRV) (time domain)

↓BMI (kg/m2)

↓WC (cm)

↑NN (ms)

↑SDNN (ms)

↑PNN50 (%)

↑RMSSD (ms)

Maniscalco et al. [41]

Lung volumes and flow rates were determined using automated equipment

+

6-min walk test

+

Oximeter

↑FVC (% pred)

↑FEV1 (% pred)

↔ FVC/FEV1

↑TLC (% pred)

↑FRC (% pred)

↑RV (% pred)

↑6-mWT distance (m)

↑HR after 6-mWT (b/min)

↑Baseline SaO2 (%)

↔ SaO2 after 6-mWT (%)

↓Dyspnea score after 6-mWT

Maser et al. [42]

Measures of HRV (e.g., power spectral analysis, RR variation during deep breathing)

+

HOMA-IR

↓BW (kg)

↓HOMA-IR

↓LF

↓HF

↓LF/HF

↑Respiration frequency area

Maser et al. [43]

RR (interval between R waves of electrocardiographic QRS complexes)

+

Stadiometer

+

Finger stick blood glucose readings

+

Hemoglobin A1c was measured by high-performance ion-exchange liquid chromatography

↓BMI (kg/m2)

↓Fingerstick glucose (mg/dl)

↓HbA1c (%)

↓Systolic blood pressure (mmHg)

↔ Diastolic blood pressure (mmHg)

↑MCR

↓E/I ratio

↑Valsalva ratio

McCullough et al. [44] Bruce treadmill protocols with gas-exchange analysis

↓BMI (kg/m2)

↔ Systolic blood pressure (mmHg)

↔ Diastolic blood pressure (mmHg)

↑Exercise duration (min)

↑Maximal HR (beats/min)

↔ Perceived exertion (Borg, 6–20)

↓VO2 peak (l/min)

↑VO2 peak (ml/kg/min)

↑V-AT (ml/kg/min)

↔ VE/VCO2 slope

Mirahmadian et al. [45] Indirect calorimeter with gas-exchange analysis

↓Body weight (kg)

↓BMI (kg/m2)

↓Fat-free mass (kg and %)

↓Fat mass (kg and %)

↓REE (kcal/day)

↑REE/FM (kcal/kg)

Nault et al. [46]

Heart rate variability (HRV) (time domain and frequency domain)

+

Echocardiogram

+

Biochemical analysis

+

HOMA-IR

↓Body weight (kg)

↓BMI (kg/m2)

↓Total cholesterol (mmol/l)

↓Triglycerides (mmol/l)

↑HDL cholesterol (mmol/l)

↓LDL cholesterol (mmol/l)

↓Glucose (mmol/l)

↓Insulin (pmol/l)

↓HOMA-IR

↓HR (beats/min)

↑SDNN (24 h)

↑rMSSD (24 h)

↑pNN50 (24 h)

↑Ln LF (ms2) (24 h)

↑Ln HF (ms2) (24 h)

↓LF/HF (24 h)

Neunhaeuserer et al. [47]

Treadmill with gas-exchange analysis

+

One-repetition maximum (1-RM)

↑Exercise time (s)

↓VO2peak (l/min)

↑VO2peak (ml/kg/min)

↑VO2/HRmax (ml/bpm)

↓OUES (ml/logl)

↔ RERmax

↑Leg extension (kg)

↔ Handgrip right (kg)

↔ Handgrip left (kg)

Notarius et al. [48] Treadmill with gas-exchange analysis

↓TEE

↑Exercise capacity

↓VO2peak (ml/kg/min)

Otto et al. [49]

Bioelectrical impedance

+

Handgrip strength

↓BMI (kg/m2)

↓Fat-free mass (kg)

↓Fat mass (%)

↓Fat mass (kg)

↔ Handgrip strength (kg) dominant hand

↔ Handgrip strength (kg) no dominant hand

Perugini et al. [50]

Heart rate variability (HRV)

+

HOMA-IR

↓BW (kg)

↓BMI (kg/m2)

HRV (improved)

↓HOMA-IR

Ravelli et al. [51]

Doubly labeled water

+

Triaxial accelerometer

↓BW (kg)

↓FM (%)

↓TEE

Remígio et al. [52] Treadmill with gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓Systolic blood pressure (mmHg)

↓Diastolic blood pressure (mmHg)

↓Resting HR (bpm)

↓Total cholesterol (mmol/l)

↓LDL cholesterol (mmol/l)

↓Triglycerides (mmol/l)

↔ Glucose (mg/dl)

↔ VO2peak (l/min)

↑VO2peak (ml/min/kg)

↓50%VO2 RP (s)

Sans et al. [53]

Homeostasis model assessment of insulin resistance (HOMA-IR)

+

Bioelectrical impedance analysis (BIA)

+

Gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓HC (cm)

↔ W/H

↓ Brachial circumference (cm)

↓Triceps skinfold thickness (cm)

↓Glucose level (mmol/l)

↓Insulin level (mmol/l)

↓HOMA-IR

↓HbA1c (%)

↑HDL cholesterol (mmol/l)

↓LDL cholesterol (mmol/l)

↓Triglyceride (mmol/l)

↓REE (kcal/day)

↑REE/BW

↓REE/FFM

Seres et al. [54] Treadmill with gas-exchange analysis

↑Exercise duration (min)

↑HRmax (bpm)

↑RERmax

↔ VO2peak (l/min)

↑VO2peak (ml/kg/min)

↔ VO2peak/FFM (ml/kg/min)

↔ VO2peak/pulse (ml/beat)

↔ Minute ventilation (l/min)

Schneider et al. [55]

Dual-energy X-ray absorptiometry

+

Indirect calorimetry

↓BW (kg)

↓BMI (kg/m2)

↓FFM (kg)

↓FM (%)

↓REE

↑REE/BW

↓Fat oxidation

↔ CHO oxidation

Silva et al. [56]

Handgrip dynamometer

+

Venous occlusion plethysmography

+

6-min walk test

↓BW (kg)

↓BMI (kg/m2)

↓HR (bpm)

↔ Systolic blood pressure (mmHg)

↔ Diastolic blood pressure (mmHg)

↓FVR (units)

↔ 30% handgrip force (Kgf)

↑6-mWT distance (m)

↓Apnea-hypopnea index

Tamboli et al. [57]

Digital scale

+

A whole-room indirect calorimeter

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓W/H (at 6th month)

↓TEE (kcal/day) (at 6th month)

↓Total RQ (at 6th month)

↓Sleep RQ (at 12th month)

↓CHO oxidation (g/kg/day) (at 12th month)

↑Fat oxidation (g/kg/day) (at 12th month)

Tam et al. [58] Metabolic chamber indirect calorimetry

↓24hrEE

↓SleepEE

↓REE

↓Spontaneous physical activity

Tettero et al. [59]

Baecke questionnaire

+

Astrand test

↓BW (kg)

↑VO2max (ml/min/KgFFM)

↑ Leisure physical activity

↑ Sport activity

Tompkins et al. [60]

Physical ability using SF-36

+

6-mWT

+

Borg RPE scale

↓BW (kg)

↓BMI (kg/m2)

↑6-mWT distance (m)

↑Physical functioning

↓Rating of perceived exertion during 6-mWT

Valezi-Machado et al. [61]

Treadmill with gas-exchange analysis

+

Transthoracic echocardiogram

↑Distance covered (m)

↑METs

↑VO2peak (ml/kg/min)

↑EF

↓Septum

Van Gemert et al. [62]

Doubly labeled water method

+

Respiration chamber

↓TEE

↓Sleep MR

↔ Physical activity index =[TEE/SMR]

↓CHO oxidation

Vargas et al. [63]

6-min walking test

+

Functional Independence Measure (FIM)

+

Timed Up-and-Go

↓HR (bpm)

↓Respiratory rate (pm)

↓Systolic arterial pressure (mmHg)

↓Diastolic arterial pressure (mmHg)

↓Borg scale

↑FIM score

Wilms et al. [64] Bicycle ergospirometry

↔ Peak workload (W)

↑Peak workload/BW (W kg−1)

↔ Test duration (s)

↔ HRmax (bpm)

↔ RERmax

↔ VO2peak (l/min)

↔ VO2peak (ml/kg/min)

↔ VO2peak/pulse (ml/beat)

↔ Ventilatory equivalent (VE/VO2)

Wu et al. [65]

Heart rate variability (HRV)

+

Insulin resistance

+

HbA1c

RMSSD improved

LF/HF ratio improved

↑Total power

↓HOMA-IR

↓HbA1c

Zavorsky et al. [66]

Bioelectrical impedance device

+

Ergocycle with gas-exchange analysis

↓BW (kg)

↓BMI (kg/m2)

↓WC (cm)

↓HC (cm)

↓W/H

↓FFM (kg)

↓FM (kg)

↓FM (%)

Rest

↔ VO2 (ml/kg/min)

↓VO2 (l/min)

↓VE (l/min) BTPS

↔ Breathing frequency (breaths/min)

↓Tidal volume (l/breath)

↓VErest/MVV

↓RER

↓HR (bpm)

At peak exercise

↑VO2 (ml/kg/min)

↔ VO2 (l/min)

↔ VE (l/min) BTPS

↔ Breathing frequency (breaths/min)

↑Tidal volume (l/breath)

↔ VEpeak/MVV

↔ RER

↔ HR (beats/min)

↔ Total time of the VO2peak test

A, peak late of diastolic filling wave velocity; AC, abdominal circumference; AI, augmentation index; AI@75, AI index standardized for a heart rate of 75 bpm; BMI, body mass index; BTPS, body temperature and pressure saturated; BW, body weight; E, peak early of diastolic filling wave velocity; E/A, velocity ratio; E/I, expiration/inspiration; EF, ejection fraction; ERV, expiratory reserve volume; FEV1, forced expiratory volume in first second; FFA, free fatty acids; FFM, fat-free mass; FM, fat mass; FRC, functional residual capacity; FVC, forced vital capacity; FVR, forearm vascular resistance; HbA1c, glycated hemoglobin; HF, high frequency; HOMA-IR, homeostatic model assessment for insulin resistance; HR, heart rate; IC, inspiratory capacity; IRV, inspiratory reserve volume; IVRT, isovolumic relaxation time; IVS, interventricular septum; La, lactate; LA, left atrium; LF, low frequency; LF/HF, low to high frequency ratio; LnRHI, reactive hyperemia index; LV, Left ventricle; MCR, mean circular resultant; MEP, maximal expiratory pressure; MET, metabolic equivalent of task; MIP, maximal inspiratory pressure; MVV, maximum voluntary ventilation; npRQ, non-protein respiratory quotient; O2-p, oxygen pulse; OGTT, oral glucose tolerance test; OUES, oxygen uptake efficiency slope = (the slope of linear regression of VO2 (L/m) versus log VE (L/m)); pNN 50 (ms), percentage of adjacent NN intervals that differ from each other by more than 50 ms; PW, posterior wall thickness; QTVI, temporal behavior of the QT variability index; REE, resting energy expenditure; RMSSD, root mean square of the successive differences; RQ, respiratory quotient; SampEn, measures of the complexity; SaO2, oxygen saturation; SDNN, standard deviation of NN intervals; SMR, sleeping metabolic ratio; SVC, slow vital capacity; TEE, total energy expenditure; TLC, total lung capacity; V-AT, ventilatory-derived anaerobic threshold; VE/VCO2, the minute ventilation/carbon dioxide production; VO2, oxygen uptake; W, watt; W/H, waist-to-hip ratio; WC, waist circumference, 50%VO2 RP, Post-exercise Oxygen Uptake Recovery Kinetics; ↑ denotes a significant increase; ↓ denotes a significant decrease; ↔, no change