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. 2021 Mar 31;11:7281. doi: 10.1038/s41598-021-86268-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of inhibiting interleukin-1β (IL-1β) activation on cytokine release from placental explants exposed to oxidative stress or hypoxia. Explants were exposed to oxidative stress (1 mM H₂O₂), or hypoxia (1%O₂), in the presence or absence of caspase 1 inhibitor (FMK002) to block inflammasome-processing of pro-IL-1 β. Cytokines were measured in conditioned medium from explants exposed to 1 mM H₂O₂: (a) IL-1α, (b) IL-1β, (c) IL-6, (d) IL-8, (e) CCL2 or 1%O2: (f) IL-1α, (g) IL-1β, (h) IL6, (i) CCL2. Line represents median, n = 8–9. Asterisks represent significant differences compared to control (con) *p < 0.05, **p < 0.01. Plus signs represent significant differences compared to H₂O₂ or 1%O₂ alone + p < 0.05. Friedman with Dunn’s multiple comparison test.