Table 3.

Potential antidepressant-like activity of selenides

	Experimental model	Minimal effective dose	Predictive tests		References
			Depression	Anxiety
(Octylseleno) xilofuranoside	–	0.001	TST	–	Brod et al. (2016)
(Fluorophenylselenyl)-2,5-diphenyl selenophene	–	50	FST	–	Gay et al. (2010)
	Corticosterone	0.1a	FST, TST	LD, NSF	Gai et al. (2014b)
	Partial sciatic nerve ligation	1	FST, TST	LD	Gai et al. (2014a)
1-Methyl-3-(phenylselanyl)-1H-indole	Streptozotocin (intracerebro ventricular)	10	FST, Splash	–	Bampi et al. (2020b)
		10a	Social interact, TST Splash	EPM	Bampi et al. (2019)
(Chlorophenyl)selanyl]-1-methyl-1H-indole	Lipopolysaccharide	1	TST Splash	EPM MB	Casaril et al. (2019b)
	Acute restrain stress	1	TST Splash	–	Casaril et al. (2019a)

Selenides (mg kg⁻¹) were intragastrically administered to Swiss mice 30 min before tests, excepting ^athat means repeated treatment (7 days),

FST forced swimming test, TST tail suspension test, LD light dark test, NSF novelty suppressed-feeding, EPM elevated plus maze, MB marble burying