Table 6.

Effects of diphenyl diselenide and its derivatives in experimental models of memory impairment

	Associated with	Experimental model	Effects	References
Diphenyl diselenide	–	Middle-aged	↑ STM, LTM	Cechella et al. (2014a)
	+ Exercise
	–	Middle-aged	↑ STM	Leite et al. (2014)
	+ Caffeine		↑ LTM
	–	Old	↑ STM, LTM, pCREB	Cechella et al. (2014b)
	+ Exercise
	–	Hypothyroidism	↑ MWM	Dias et al. (2012)
	–	Menopause	↑ MWM, AChE	da Rocha et al. (2012b)
p-Chloro-diphenyl diselenide	–	Old	↑ LTM	Bortolatto et al. (2012)
p-Methoxyl-diphenyl diselenide	–	Sporadic AD	↑ MWM, SDPA,YM	Pinton et al. (2011, 2013a, b)
	–	Aβ-fragment 25–35	↓cell death, apoptosis, ↑ MWM	Pinton et al. (2013c)

old 24 months old, middle-aged 18 months old, LTM long-term memory, STM short-term memory, MWM Morris water maze, SDPA step-down passive avoidance, YM Y maze, AChE acetylcholinesterase activity