Table 2.
Comparison of markers of thrombin generation and inflammation in PNH patients and controls
| PNH (N = 18) Mean (95% CI) |
Controls (N = 35) Mean (95% CI) |
PNH versus controls P value |
|
|---|---|---|---|
| TAT (ng/ml) |
5.06 (3.98, 6.14) |
3.39 (2.62, 4.16) |
0.016 |
| sP-selectin (ng/ml) |
80.57 (61.5, 99.7) |
44.67 (39.5, 49.8) |
0.002 |
| IL-6 (pg/ml) |
2.75 (1.41, 4.09) |
2.0 (1.4, 2.6) |
0.327 |
| D-Dimer (ng/ml) |
936 (559, 1310) |
Normal control values: TAT: < 2.90 ng/ml; sP-selectin: < 58.41 ng/ml; D-Dimer: < 500 ng/ml
PNH paroxysmal nocturnal hemoglobinuria, TAT thrombin–antithrombin complex, sP-selectin soluble P-selectin, IL-6 interleukin-6