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. 2021 Mar 18;8:622573. doi: 10.3389/fmed.2021.622573

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Copyright © 2021 El-Kadiry, Lumbao, Rafei and Shammaa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution of disc quality 8–12 months post-injection in disc provocation-positive group as assessed with MRI. (A) Representative MRI scan showing the evolution of IVD (sagittal plane) and spinal canal space (axial view) at L5-S1 from baseline to 11 months post-injection. Disc height was elevated from 7.19 to 8.19 mm. Canal space size increased from 15.54 to 16.86 mm. (B) Scatter plot of disc height (mm) evolution with interpolation lines ^**p = 0.001 (Paired t-test of means, n = 16 discs of 9 patients). (C) Scatter plot of canal space (mm) evolution with interpolation lines ^**p = 0.001 (Paired t-test of means, n = 16 discs of 9 patients). (D) Bar graph showing the percentage of disc changes after injection. ^***P = 0.001 (Chi-Square test, n = 16 discs of 9 patients).