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Diagram showing crosstalk between the hypothalamic pituitary GH and IGF-1 axis and endocrine organs – testis in men, ovaries in woman and adipose tissue and adrenal gland in both sexes. All these tissue express the GHR and IGF1R and are also involved in the production of estrogens and androgens. GH, IGF and sex steroid autocrine and paracrine signalling can influence the development of endocrine-related cancers such as breast and prostate. Created with BioRender.com.
