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. 2021 Mar 18;12:631881. doi: 10.3389/fimmu.2021.631881

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Copyright © 2021 Ertle, Rommel, Tumala, Moriwaki, Klein, Kruse, Gieler and Peters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCs are targets of SLURP-1 in the skin. (A–D) immunohistology and (E,F) HM of Chrna7 and SLURP-1 in full-thickness skin samples obtained from control and 24 h noise-stressed mice. In photomicrographs, sMC are labeled green, Chrna7 and SLURP-1 red. Each dot in the graphs represents one mouse. (G–I) cMC stimulation with SLURP-1 yielded comparable results to stimulation with the stress mediator SP and standard MC degranulators DNP-HSA, Ionomycin, Ionomycin and PMA. P < 0.01 = *. Scale bars: (A,B) 25 μm and (C,D) 10 μm. Chrna, alpha nicotinic acetylcholine receptor; DNP-HSA, Dinitrophenyl Albumin; NGF, Nerve Growth Factor; PMA, Phorbol 12-myristate 13-acetate; SLURP, secreted Ly-6/uPAR-related protein.