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. 2021 Mar 18;12:658620. doi: 10.3389/fmicb.2021.658620

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Copyright © 2021 Sun, Ji, Zheng, Wang, Cao, Wan, Li, Rong, He, Chen, Zhang and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of coverage and identity threshold choice on the results. (A) Number of predicted PDEs under different thresholds. (B) Venn diagram of correlated enzyme pairs predicted with different thresholds (main set, identity 30%; additional set 1, identity 25%; additional set 2, identity 50%; coverage 80% for all sets). Enzyme pairs with the Pearson correlation coefficient |r| > 0.4 and p < 0.05 were regarded as correlated. The number of correlated enzyme pairs for each data set was indicated in parentheses beside the set identity.