TABLE 3.
Metabolites that associate with chronic thromboembolic pulmonary hypertension (CTEPH) and show significant gradients between sampling sites
| Subpathway | Superpathway | Gradients | ||||||
| PA–ART | SVC–PA | ART–SVC | ||||||
| FC | FDR p-value | FC | FDR p-value | FC | FDR p-value | |||
| α-Ketoglutarate | TCA cycle | Energy | −0.184 | <0.001 | −0.269 | <0.001 | −0.453 | <0.001 |
| N-Acetylmethionine | Methionine, cysteine, SAM and taurine metabolism | Amino acid | 0.087 | 0.038 | −0.152 | <0.001 | ||
| Oxalate (ethanedioate) | Ascorbate and aldarate metabolism | Cofactors and vitamins | −0.288 | <0.001 | −0.282 | <0.001 | ||
| Glycerate | Glycolysis, gluconeogenesis and pyruvate metabolism | Carbohydrate | −0.36 | <0.001 | −0.403 | <0.001 | ||
| 2-Hydroxypalmitate | Fatty acid, monohydroxy | Lipid | −0.304 | 0.002 | −0.414 | <0.001 | ||
| N-Acetylvaline | Leucine, isoleucine and valine metabolism | Amino acid | 0.118 | 0.003 | 0.052 | 0.026 | ||
| N-Formylmethionine | Methionine, cysteine, SAM and taurine metabolism | Amino acid | −0.185 | <0.001 | ||||
| 7-Methylguanine | Purine metabolism, guanine containing | Nucleotide | −0.165 | <0.001 | ||||
| Sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)# | Sphingomyelins | Lipid | 0.119 | <0.001 | ||||
| γ-Glutamyl-ε-lysine | γ-Glutamyl amino acid | Peptide | −0.265 | 0.002 | ||||
| Sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)# | Sphingomyelins | Lipid | 0.085 | 0.005 | ||||
| N-Acetylserine | Glycine, serine and threonine metabolism | Amino acid | −0.108 | 0.008 | ||||
| 1,2-Dilinoleoyl-GPC (18:2/18:2) | Phosphatidylcholine | Lipid | 0.1 | 0.008 | ||||
| Androsterone sulfate | Androgenic steroids | Lipid | 0.067 | 0.012 | ||||
| 1-Stearoyl-2-arachidonoyl-GPC (18:0/20:4) | Phosphatidylcholine | Lipid | 0.145 | 0.013 | ||||
| Sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)# | Sphingomyelins | Lipid | 0.11 | 0.018 | ||||
| Tryptophan | Tryptophan metabolism | Amino acid | 0.109 | 0.018 | ||||
| N-Acetylalanine | Alanine and aspartate metabolism | Amino acid | −0.128 | 0.022 | ||||
| 1-Linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)# | Phosphatidylcholine | Lipid | 0.099 | 0.03 | ||||
| N-Acetylphenylalanine | Phenylalanine metabolism | Amino acid | 0.092 | 0.033 | ||||
| Sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) | Sphingomyelins | Lipid | 0.083 | 0.045 | ||||
| 1-(1-Enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)# | Plasmalogen | Lipid | 0.068 | 0.046 | ||||
PA: pulmonary artery; ART: radial artery; SVC: superior vena cava; FC: fold change; FDR: false discovery rate (corrected p-values displayed); TCA: tricarboxylic acid; SAM: S-adenosyl methionine. #: probable metabolite identity, but unconfirmed (see methods).