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. 2021 Mar 31;11:7288. doi: 10.1038/s41598-021-86646-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNAseq identifies reversion of the global transcriptome and a differentiation signature following DOT1L inhibition. (a–c) Volcano plots representing gene expression in the following comparisons: Smc3het-DMSO vs WT-DMSO (a), Smc3het-Inhibitor vs Smc3het-DMSO (b), and Smc3het-Inhibitor vs WT-Inhibitor (c). Red dots indicate HoxA9 and DOT1L expression for reference. (d) Heatmap illustrating the expression of differentially regulated genes across all 4 conditions. (e) GSEA plot of a geneset for Myeloid Development, with corresponding statistics below.