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. 2021 Mar 31;11:7246. doi: 10.1038/s41598-021-86431-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chronological changes in the number of reported cases of legionellosis in Japan, 1999–2017. The urinary antigen test was introduced in a clinical guideline by the Japanese Respiratory Society in 2005. Then, LAMP (Loop-mediated Isothermal Amplification) method for the diagnosis of legionellosis was approved by the medical insurance in 2011.