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. 2021 Mar 31;11:7311. doi: 10.1038/s41598-021-86484-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Paclitaxel (PTX) and lipid vectors. (a) Chemical structure of PTX. (b) A unilamellar liposome consisting of a self-assembly of amphiphilic lipid molecules. The liposome can carry hydrophobic molecules (red spheres) within its hydrophobic bilayer and hydrophilic molecules (yellow oval) in its aqueous interior. (c) Chemical Structures of DLin-MC3-DMA (the cationic lipid used in patisiran), DOTAP, DOPC (the lipids used in the Endo-TAG formulation of PTX) and DLinPC. The cis double bonds in the lipid tails are highlighted. (d) Space filling molecular models of the ground state structure of oleic acid (C18:1) and linoleic acid (C18:2) together with two views of the structure of PTX for size comparison. The structures were rendered using RasTop 2.2 (https://www.geneinfinity.org/rastop/).