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. 2021 Mar 18;9:619197. doi: 10.3389/fcell.2021.619197

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Copyright © 2021 Van houcke, Mariën, Zandecki, Seuntjens, Ayana and Arckens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in the lifespan between mammals and teleost fish and the occurrence of brain aging hallmarks. While medaka, goldfish, brown ghost knifefish, and zebrafish have a lifespan longer or comparable to mouse, the killifish has a mean lifespan that is eight times shorter. In the killifish brain, cellular and molecular aging hallmarks are already observed from 9 weeks of age. For comparison, the occurrence of important hallmarks of brain aging is linked to the timelines, based on observations in zebrafish and killifish. Yrs, years; W, weeks; PD, Parkinson’s disease-like phenotype; MtDNA, mitochondrial DNA.