Table 6.

Association of intronic MYOM1 gene alterations with demographic and clinicopathological variables in 444 subjects (224 cases and 220 controls)

Parameters	MYOM1 c.1022+23 (G>A; rs17177479)		OR (95% CI)	P value	MYOM1 c.3418+44 (G>T; rs55779127)		OR (95%CI)	P value	MYOM1 c.3418+65 (C>G; rs8096379)		OR (95%CI)	P value
	GG	GA+AA			GG	GT+TT			CC	CG+GG
Age
≤30 years	213	54	Ref. (1.00)		140	127	Ref. (1.00)		140	127	Ref. (1.00)
>30 years	151	26	1.4 (0.88-2.4)	0.06	110	67	1.5 (1.01-2.1)	0.02	110	67	1.5 (1.01-2.1)	0.02
Gender
Male	220	50	Ref. (1.00)		152	118	Ref. (1.00)		150	120	Ref. (1.00)
Female	144	30	1.09 (0.66-1.7)	0.3	98	76	1.0 (0.68-1.4)	0.5	100	74	1.08 (0.7-1.5)	0.3
Smoking Status
Non-Smoker	70	15	Ref. (1.00)		65	20	Ref. (1.00)		60	25	Ref. (1.00)
Passive Smoker	230	45	1.09 (0.57-2.0)	0.3	140	135	0.3 (0.2-0.5)	0.001	145	130	0.4 (0.2-0.78)	0.001
Active Smoker	64	20	0.6 (0.3-1.4)	0.16	45	39	0.3 (0.2-0.7)	<0.001	45	39	0.5 (0.2-0.9)	0.01
Occupation
Student	115	15	Ref. (1.00)		55	75	Ref. (1.00)		55	75	Ref. (1.00)
Near Workers	135	45	0.4 (0.2-0.7)	0.001	85	95	1.2 (0.7-1.9)	0.2	85	95	1.2 (0.7-1.9)	0.1
Others	114	20	0.7 (0.3-1.5)	0.2	110	24	6.2 (3.5-10.7)	<0.001	110	24	6.2 (3.5-10.9)	<0.001
Family History
No	60	20	Ref. (1.00)		20	60	Ref. (1.00)		20	60	Ref. (1.00)
Yes	136	08	5.6 (2.3-13.5)	<0.001	10	134	0.2 (0.09-0.5)	<0.001	10	134	0.2 (0.09-0.5)	<0.001
Degree of Myopia
<-6 D	106	18	Ref. (1.00)		22	102	Ref. (1.00)		20	104	Ref. (1.00)
≥-6 D	90	10	1.5 (0.6-3.4)	0.15	08	92	0.4 (0.17-0.9)	0.01	10	90	0.5 (0.2-1.2)	0.09

D; Diopters.