Table 7.
Association of EMILIN2 and DLGAP1 gene alterations with demographic and clinicopathological variables in 444 subjects (224 cases and 220 controls)
| Parameters | EMILIN2 Asn451Asn (T>C; rs3810067) | OR (95% CI) | P value | DLGAP1 Pro517Pro (G>A; rs3745051) | OR (95%CI) | P value | ||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| TT | TC+CC | GG | GA+AA | |||||
| Age | ||||||||
| ≤30 years | 204 | 63 | Ref. (1.00) | 207 | 60 | Ref. (1.00) | ||
| >30 years | 142 | 35 | 1.2 (0.78-1.9) | 0.1 | 157 | 20 | 2.2 (1.3-3.9) | <0.001 |
| Gender | ||||||||
| Male | 215 | 55 | Ref. (1.00) | 220 | 50 | Ref. (1.00) | ||
| Female | 131 | 43 | 0.7 (0.5-1.2) | 0.1 | 144 | 30 | 0.86 (0.5-1.4) | 0.2 |
| Smoking Status | ||||||||
| Non-Smoker | 60 | 25 | Ref. (1.00) | 65 | 20 | Ref. (1.00) | ||
| Passive Smoker | 215 | 60 | 1.5 (0.8-2.5) | 0.07 | 235 | 40 | 1.8 (0.9-3.3) | 0.03 |
| Active Smoker | 70 | 13 | 2.2 (1.0-4.8) | 0.01 | 64 | 20 | 0.9 (0.4-2.0) | 0.4 |
| Occupation | ||||||||
| Student | 95 | 35 | Ref. (1.00) | 115 | 15 | Ref. (1.00) | ||
| Near Workers | 135 | 45 | 1.1 (0.6-1.8) | 0.3 | 140 | 40 | 0.4 (0.2-0.8) | 0.007 |
| Others | 116 | 18 | 2.3 (1.2-4.4) | 0.003 | 109 | 25 | 0.5 (0.2-1.1) | 0.06 |
| Family History | ||||||||
| No | 52 | 28 | Ref. (1.00) | 60 | 20 | Ref. (1.00) | ||
| Yes | 134 | 10 | 7.2 (3.2-15.9) | <0.001 | 84 | 60 | 0.4 (0.2-0.8) | 0.006 |
| Degree of Myopia | ||||||||
| <-6 D | 112 | 12 | Ref. (1.00) | 69 | 55 | Ref. (1.00) | ||
| ≥-6 D | 74 | 26 | 0.3 (0.1-0.6) | <0.001 | 75 | 25 | 2.3 (1.3-4.2) | 0.001 |
D; Diopters.