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. 2021 Feb 15;12(1):35–48.

Table 8.

Appropriate genetic association models for SNPs in MYOM1, EMILIN2 and DLGAP1 genes with response to HM phenotype (n = 444, adjusted by gender and age)

Gene/variation Model Genotype Case; n (%)n=224 Control; n (%) n=220 P Value AIC
MYOM1 Gly333Gly (G>A; rs2230162) Overdominant G/G+A/A 196 (87.0) 128 (58.0)
G/A 28 (13.0) 92 (42.0) <0.0001 1319.44
MYOM1 Gly341Ala (G>C; rs8099021) Recessive G/G+G/C 32 (14.0) 68 (31.0)
C/C 192 (86.0) 152 (69.0) <0.0001 1081.20
MYOM1 c.1022+23 (G>A; rs17177479) Overdominant G/G+A/A 224 (100.0) 168 (76.0) <0.0001 1196.02
G/A 00 (0.0) 52 (24.0)
MYOM1 c.3418+44 (G>T; rs55779127) Overdominant G/G+T/T 30 (13.0) 220 (100.0) <0.0001 144488.4
G/T 194 (87.0) 00 (0.0)
MYOM1 c.3418+65 (C>G; rs8096379) Recessive C/C+C/G 224 (100.0) 220 (100.0)
G/G 00 (0.0) 00 (0.0) <0.0001 44797.3
EMILIN2 Asn451Asn (T>C; rs3810067) Codominant T/T 186 (83.0) 160 (73.0)
T/C 38 (17.0) 60 (27.0) <0.0001 1087.4
C/C 00 (0.0) 00 (0.0)
DLGAP1 Pro517Pro (G>A; rs3745051) Recessive G/G+G/A 224 (100.0) 220 (100.0)
A/A 00 (0.0) 00 (0.0) <0.001 514.14