Skip to main content
. 2021 Feb 15;9(1):101–120.

Figure 2.

Figure 2

Combination treatments with Simvastatin Derivative SVA. A. LNCaP-AI cells were plated for 3 days in regular medium before being adjusted to steroid-reduced conditions for 2 days. Cells were then treated with 2.5 μM SVA and/or 5 μM abiraterone acetate for 3 days in steroid-reduced conditions. Cell number was determined with trypan blue exclusion dye assay. Results presented are mean ± SE. n=3. *P<0.05 (Unpublished data). B. LNCaP-AI cells were plated for 3 days in regular medium before being adjusted to steroid-reduced conditions for 2 days. Cells were then treated with 2.5 μM SVA and/or 1 nM docetaxel for 3 days in steroid-reduced conditions. Cell number was determined with trypan blue exclusion dye assay. Results presented are mean ± SE. n=3. *P<0.05 (Unpublished data) C. LNCaP-AI cells were plated for 3 days in regular medium before being adjusted to steroid-reduced conditions for 2 days. Cells were then treated with 5 μM SVA and/or 500 nM of the CIL-102 derivatives 1, 22, or 23 for 3 days in steroid-reduced conditions. Cell number was determined with trypan blue exclusion dye assay. Results presented are mean ± SE. n=3. *P<0.05 (Unpublished data). D. Chemical structures of CIL-102 derivatives 1, 22, and 23.