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. 2021 Mar 18;9:633607. doi: 10.3389/fcell.2021.633607

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Copyright © 2021 Fu, Bao, Liu, He, Wen, Liu, Xu, Jin and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of the hypoxia-associated prognostic signature in the Target database. (A) Univariate cox regression analysis of hypoxia-associated DEmRNAs revealed six prognostic genes. (B) Multivariate cox regression analysis revealed two independent hypoxia-associated DEmRNAs. (C) The heatmap of P4HA1 and DCN in high- and low-risk groups showed that P4HA1 was positively correlated with risk score while DCN showed the opposite trend. (D) The scatter plot of patients’ risk scores and survival time. (E) Kaplan–Meier survival plot of patients in high- and low-risk groups. (F) Time-dependent ROC curve at 1, 3, and 5 years of hypoxia-associated prognostic signature. DEmiRNA, differentially expressed microRNA; ROC, receiver operating characteristic; P4HA1, prolyl 4-hydroxylase subunit alpha 1; DCN, decorin.