TABLE 1.

MR estimates from each method assessing the causal effects of UC, CD, and IBD on PSC.

Exposure traits	MR methods	PSC
		Number of SNPs	OR(95% CI)	SE	MR p-value	MR-Steiger test
IBD	MR Egger	112	1.16 (0.82∼1.63)	0.17	0.41	TRUE
	Inverse variance weighted	112	1.29 (1.12∼1.50)	0.08	<0.01
	Maximum likelihood	112	1.31 (1.23∼1.34)	0.03	<0.01
	Weighted median	112	1.24 (1.10∼1.40)	0.06	<0.01
	Robust adjusted profile score (RAPS)	112	1.29 (1.16∼1.44)	0.05	<0.01
UC	MR Egger	73	1.13 (0.80∼1.61)	0.18	0.50	TRUE
	Inverse variance weighted	73	1.48 (1.27∼1.72)	0.08	<0.01
	Maximum likelihood	73	1.52 (1.42∼1.63)	0.04	<0.01
	Weighted median	73	1.31 (1.15∼1.49)	0.06	<0.01
	Robust adjusted profile score (RAPS)	73	1.40 (1.23∼1.58)	0.06	<0.01
CD	MR Egger	99	1.06 (0.75∼1.50)	0.18	0.74	TRUE
	Inverse variance weighted	99	1.13 (0.99∼1.28)	0.07	0.07
	Maximum likelihood	99	1.13 (1.07∼1.20)	0.03	<0.01
	Weighted median	99	1.12 (1.02∼1.24)	0.05	0.02
	Robust adjusted profile score (RAPS)	99	1.13 (1.02∼1.26)	0.05	0.02