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. 2021 Jan 18;61(3):180–202. doi: 10.1002/jobm.202000537

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© 2021 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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SARS‐CoV‐2 nonstructural proteins (nps), replication cycle, and host pathogenesis. The multiple interactions or the complexes which acts as activators are essential for the virus replication. Numbers on polypeptide pp1a/b labels the nsps; white dots: cleavage made by nsp3; orange dots: nsp5 (Mpro/3CLpro) cleave sites. Brown arrow: nsp–nsp interactions. The portion of the figure with faint blue background specifies the role of nsps in host pathogenesis. Figure created with BioRender.com